While AKT inhibition did not alter the number of CC3-positive apoptotic cells relative to the vehicle control, a marginal trend for a reduction in the percentage of PCNA-positive cells was observed in CU-PC01 PDX explants upon capivasertib treatment ( Figure 7 D–F), albeit not statistically significant.
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Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer.
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