Polyploidy Promotes Hypertranscription, Apoptosis Resistance, and Ciliogenesis in Cancer Cells and Mesenchymal Stem Cells of Various Origins: Comparative Transcriptome In Silico Study.

The functional enrichment analysis of 358 ploidy-upregulated genes and 113 upregulated master regulators ( Supplementary Tables S1 and S2 ), using the collection of gene signatures, revealed the highly significant upregulation of “housekeeping genes”, “top 10% AT3 SW-degenerate synonymous sites”, and “top 10% selection-favored in primates vs. rodents” ( Table 1 ).

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