Although we did not observe a significant difference between doses, there was an overall trend of down regulation of both Phosphor‐RB and Cyclin D1 across cell lines suggesting an initiation of senescence phenotype while inhibiting cell proliferation (Figure 2B ). 3.3 DFMO inhibits neurosphere formation and progression in neuroblastoma cell lines We investigated the effect of DFMO on sphere initiation, formation, and development in different cell lines.
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