Diagnostics of Tuberculosis with Single-Walled Carbon Nanotube-Based Field-Effect Transistors.

To prove the hypothesis, we performed FET measurements on SWCNT devices before and after the antibody functionalization. The calibration plot ( Figure S6 ) showed a decreasing trend first (0–5 μg), which can be explained as the change of electronic properties of the metal–nanotube contact due to protein adsorption. 42 Then, the response became relatively stable, proving the antibody loading saturation happened when 5 μg of Ab85B was introduced onto SWCNT devices.

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With the increasing antigen concentration, the characteristic curves shifted to more positive gate voltages, the threshold voltage showed an increasing trend ( Figure S8 ), and the curve’s linear region slope decreased ( Figure S9 ).

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