Barely Significant
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Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis.

PLoS Pathog · 2024 · PMC11062541 · PMID 38640137

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highly significantno p-value reported
The highly significant decrease in excision frequency after attL deletion suggests that SezA prevents ICE Ssu HN105 excision from the chromosome by binding to the attL site, which maintains the genetic stability of ICE ( Fig 4J ).

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