Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells.

Among nonresponders, a nonsignificant trend toward fewer epithelial cells ( P = .13) more frequently expressing HLA-DR ( P = .16) in the biopsies of vedolizumab recipients than control individuals suggests that the degree of colonic inflammation may differ between these 2 subgroups, with control individuals being slightly less inflamed ( Supplementary Figure 2E , F ).

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