a trend toward significanceP < 0.1
P > 0.05 was considered statistically significant, but P < 0.1 was considered as a trend toward significance and indicated with # . # P < 0.1, * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.
P > 0.05 was considered statistically significant, but P < 0.1 was considered as a trend toward significance and indicated with # . # P < 0.1, * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.