Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis.

hepaticus , these T cell-specific transcription-factor-deficient mice developed colitis with varying degrees of pathology, with an overall trend of double-deficient Prdm1 fl/fl Maf fl/fl Cd4 Cre mice developing the most severe disease, and the Prdm1 fl/fl Cd4 Cre and Maf fl/fl Cd4 Cre mice each developing mild to moderate colitis, respectively compared to Prdm1 fl/fl Maf fl/fl control mice (hereafter referred to as control mice), which showed no inflammation or colitis (Fig. 1a–c and Methods ).

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