Systematic identification and characterization of exon-intron circRNAs.

Specifically, among the 32 serine-rich and HNRNP splicing factors that are known to regulate splicing by direct intronic binding, 27 showed a decreasing trend during differentiation ( Fig. 7 E).

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By plotting the retained introns along their host transcripts, we observed an evident trend that CIRs peaked at the 5′ portion of the transcripts, whereas LIRs peaked at the 3′ portion of the transcripts in five data sets from four cell lines ( Fig. 4 H; Supplemental Fig.

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