The expression of the two KPGs (IFIT3 and SAMD9) showed an increasing trend, which was validated in the GSE127952 dataset (pSS: n = 8, Control: n = 6; Brazil) and the GSE154926 dataset (pSS: n = 43, Control: n = 7; USA), although only SAMD9 expression in the GSE127952 dataset was upregulated significantly in pSS patients ( P = 0.00056, Fig. 4 H and I).
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WGCNA and machine learning analysis identifi ed SAMD9 and IFIT3 as primary Sjögren's Syndrome key genes.
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