The titers of antinuclear antibodies are associated with the degree of inflammation and organ damage in Primary Sjögren's Syndrome.

Furthermore, as the antinuclear antibody titer level increased, the levels of complement C3 and complement C4 showed a decreasing trend.

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We also found that with increasing antinuclear antibody titer levels, there was an increasing trend in ESR, RF, and salivary flow rate (left), but only the difference between Group 5 (antinuclear antibody titer ≥ 1:10,000) and Group 1 (antinuclear antibody titer < 1:320) was statistically significant ( P < 0.05).

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