RA is a major global public health challenge, according to the global epidemiological study on RA in 2017, the age-standardized global prevalence and annual incidence rates of RA were 0.246 % and 0.015 %, which show an increasing trend [ 2 , 3 ].
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Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012.
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