In contrast to the in vitro models, GSEA analysis of both the KO x PyMT and Genetrap x PyMT tumors demonstrated a highly significant suppression (FDR < 0.001) of EMT-associated transcriptional programs in the autochthonous setting ( Fig 8A and 8B ).
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Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer.
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