In vivo base editing of a pathogenic Eif2b5 variant improves vanishing white matter phenotypes in mice.

In alignment with our flow cytometry analysis ( Figure 5 D), no pronounced changes in normalized protein abundances were detected for markers of oligodendrocyte maturation or myelination ( Figure 5 F, top), but in half of the ABEmax-treated mice (n = 3) we observed a slight trend for increased abundance of various markers for astrocyte maturation (subset 1 in Figure 5 F).

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