Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice.

Prevotellaceae_UCG-001 was found to promote indirectly fiber degradation to produce short SCFAs and showed a positive trend with other SCFAs-producing bacteria. 29 30 SCFAs could improve glucose homeostasis and insulin function by effectively regulating glucose absorption and utilization in liver, skeletal muscle and adipose tissue. 31 In our study, the combined treatment could restore the reduced abundance of Prevotellaceae_UCG-001 , while metformin monotherapy had no such effect.

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