Prognostic impact of chronic lymphocytic leukemia comorbidity index in a young population: a real-world evidence study of a national gulf region cohort.

When adjusting for age ≥ 65 at diagnosis (which was a significant predictor of OS in the univariable model, see Table 2 ), disease stage, and TP53 aberration, intermediate/high risk CLL-CI patients had shorter OS at borderline significance levels ( n = 165; intermediate vs. low risk: HR = 4.59 [95%CI, 1.00-20.96], p = 0.049; high vs. low risk: HR = 3.99 [95%CI, 0.85–18.68], p = 0.079; c-index = 0.70).

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