CYB561 supports the neuroendocrine phenotype in castration-resistant prostate cancer.

Knockdown of CYB561 decreased Fe 2+ levels ( Fig 6A ), led to a decreasing trend in total iron concentration ( S9D Fig ), upregulated TFRC expression ( Fig 6B ), and downregulated FTH1 ( Fig 6C ) and FPN1 ( Fig 6D ) expression.

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