Effects of DNA methylation and its application in inflammatory bowel disease (Review).

To add to the premise that the IL23R gene is involved in IBD, Duerr et al ( 54 ) discovered an extremely significant correlation between CD and the IL23R gene on chromosome 1p31, which codes for a portion of the receptor for the proinflammatory cytokine IL-23, and this further increases the evidence that the IL-23 pathway is harmful in human illnesses, as suggested by the genome-wide association studies (GWAS) findings ( 55 ).

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