Plasma oxysterols are associated with serum lipids and dementia risk in older women.

8 Higher dementia risk observed in those with a higher 24‐OHC/27‐OHC ratio is in agreement with the marginally significant findings of increased cognitive impairment risk reported by Hughes et al., but, in contrast, we did not observe a relationship between 24‐OHC levels and dementia risk in our exclusively female sample. 45 Nonetheless, our study is the first to report significantly greater dementia risk in relation to higher 24‐OHC/27‐OHC, and specifically in APOE 3 and APOE 4+ carriers.

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