In a global evaluation of CRC incidence across 39 countries with varying Human Development Index (HDI) rankings, it has been noted that countries with medium to high HDI levels have shown an increasing trend in CRC occurrences in recent years, while high-HDI nations exhibit a decreasing trend. 34 Another study by Xi and Xu in 2021 emphasized a growing trend of CRC in middle- and low-income countries.
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Colorectal Cancer Incidence in Iran Based on Sex, Age, and Geographical Regions: A Study of 2014-2017 and Projected Rates to 2025.
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In this context, there has been an increasing trend in the number of individuals diagnosed with CRC in Iran. 13 Currently, CRC is the third most common cancer in men and the second in women in Iran. 14 Although CRC was the 7th leading cause of disability-adjusted life years (DALYs) among Iranian men and the 25th among Iranian women in 1990, it rose