Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients.

Alzheimers Res Ther · 2024 · PMC11097559 · PMID 38755703

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hedged sentences

0.0510

closest p · 1.0× alpha

0.5000

boldest claim

The sentences

a trend toward significancep = 0.051so close (0.05 < p ≤ 0.1)

In MCI, LME models revealed that cognitive decline was significantly predicted by NfL (β=-0.43, p = 0.006), GFAP (β=-0.38, p = 0.015), and a trend toward significance was observed in Aβ42/40 (β = 0.34, p = 0.051).

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a trend towards significancep < 0.1so close (0.05 < p ≤ 0.1)

Nonetheless, our findings reveal a trend towards significance (i.e., p < 0.1), thus a smaller predictive power of Aβ42/40 when compared to NfL and GFAP.

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marginally significantp = 0.5not close (p > 0.1)

The only exception was GFAP, which was significantly increased in CU participants with hypercholesterolemia ( p = 0.01) and a marginally significant decrease in MCI participants with diabetes ( p = 0.5; Figure S1 in Supplementary Materials).

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