An altered plasma lipidome-phenome network characterizes heart failure with preserved ejection fraction.

In the HFpEF group, multiple significant positive correlations were inferred (FDR < 0.1), which were absent or failed to reach significance in the control group, including positive correlations between CE23:2;0 and LVEDD ( r = 0.61), PC18:1;0–20:3;0 and heart rate (b.p.m.) ( r = 0.45), PC16:1;0–18:2;0 and LAVI ( r = 0.52), and LPC20:4;0 and LVEF ( r = 0.54) ( Figure 7 ).

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