It is therefore highly significant that the interaction of Nb-Activator-76 with the P2-M4 loop also induces a displacement in the top of the M4 helix similar to that seen in the ML335-bound structures of TREK-2 (Fig. 4E ).
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Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
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