Complementation testing identifies genes mediating effects at quantitative trait loci underlying fear-related behavior.

The first, on chromosome 16, had a highly significant association (log p = 9.48) and lies in an intron of a cell adhesion molecule, Lsamp (limbic system-associated membrane protein), whose deletion is known to alter behavior in the EPM. 68 , 69 We found a significant interaction ( p = 0.001; Table 1 ), indicating that the effect of the QTL is mediated by the Lsamp gene.

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