Multiple progression contributed to poorer OS though barely failed to attain statistical significance (HR, 3.26; 95 % CI, 0.94–11.28; p = 0.062).
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A real-world analysis of stereotactic body radiotherapy combined with immunotherapy in advanced or recurrent non-small cell lung cancer (NSCLC): A single-center experience.
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a favorable trendp = 0.319
Comparing to treating only part of metastatic lesions, total irradiation of metastatic lesions was associated with superior PFS (HR, 0.44; 95 % CI, 0.18–1.11; p = 0.083), and higher radiation doses (BED 10 ≥ 60 Gy) showed a favorable trend to improve the PFS (HR, 0.71; 95 % CI, 0.36–1.39; p = 0.319).
In our results, radiation regimens with BED 10 ≥ 60 Gy, for instance, 10 Gy × 3 regimen, showed a pronounced trend to improve the outcomes comparing to those with lower BED 10 in both Group 1 and 2.
While in Group 2 for whom received salvage SBRT to the progressed tumors, it seemed that there was barely significant factor correlated with treatment outcomes.
Univariate and multivariate analysis for PFS and OS As shown in Table 2 , in Group 1, multiple metastases were associated with poor PFS (HR, 3.59; 95 % CI, 1.89–6.83; p < 0.001), so as the squamous cell carcinoma (HR, 1.92; 95 % CI, 0.96–3.81; p = 0.064) with a borderline significance.