A 3D organoid platform that supports liver-stage <i>P.falciparum</i> infection can be used to identify intrahepatic antimalarial drugs.

The remaining EEFs showed a decreasing trend in the expression of the PfMSP-1 EEF maturation signal, with a relative expression of 12.16 (±s.d. 6.57), 10.0 (±s.d. 6.30) and 8.73 (±s.d. 5.04) in the Mock, PYR and K98-treated conditions respectively ( Fig. 3 E).

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When averaged per donor, the expected donor-specific variability in EEFs sizes was observed, with an increasing trend in EEFs sizes through days with average sizes of 7.72 (±s.d. 2.23) μm, 9.55 (±s.d. 1.88) μm and 9.75 (±s.d. 2.44) μm at Days 3, 6 and 9 post-infection respectively ( Fig.

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