H3K27Me3 abundance increases fibrogenesis during endothelial-to-mesenchymal transition via the silencing of microRNA-29c.

This increase was blunted in H3K27Me3-deficient HUVEC ( Figure 6 ), whereas the simultaneous blunting of miR-29c expression partly restored COL1A1 expression again by 2.0-fold (gene expression), although this failed to reach significance and collagen I expression by 1.6-fold and collagen III expression by 2.5-fold compared to HUVEC only deficient in H3K27Me3 ( Figures 6A–D ).

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