Design of potent tyrosinase inhibiting <i>N</i>-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies.

The molecule 9f in which the methyl group was at ortho -position and closer to the benzamido group displayed superb activity while a decreasing trend was observed when the methyl group was present away from the benzamido group, in meta and para -isomer ( Fig. 10 ).

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