The resulting normal distribution had mean MFE of −21.12 kcal/mol (standard deviation = 2.67, 500×), revealing that the predicted three-stemmed pseudoknot structure of the native sequence is highly significant with a z -score of −2.05 and a p value of 0.02 (one-tailed Student's t -test).
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A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal.
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