Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer.

Fruits Based on the 3-DF joint test, rs1620977 in NEGR1 showed a highly significant combined effect ( Supplemental Figure S3b ; 3-DF p-value: 3.4 × 10 −8 ) with no direct CRC associations (D|G p-value: 0.77), but with a highly significant association with fruit intake (G|E p-value: 1.0 × 10 −8 ), and a modest interaction with fruits on risk of CRC (G × E p-value: 0.03) ( Table 2 ).

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