Under these conditions, FK506 treatment appeared to slightly improve motor behavior compared to vehicle-treated Ppt1 −/− counterparts, though the effect did not quite reach statistical significance ( p = 0.059, Student’s t -test vs. vehicle-treated Ppt1 −/− mice) ( Figure 7E ).
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Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis.
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