Use of Optical Redox Imaging to Quantify Alveolar Macrophage Redox State in Infants: Proof of Concept Experiments in a Murine Model and Human Tracheal Aspirates Samples.

After a 30-minute exposure to 450 μM H 2 O 2 , in comparison with the respective ones without H 2 O 2 exposure, there was a significant increase in Fp at caffeine doses of 50 μM and 1000 μM, a highly significant decrease in NADH at all caffeine doses except 1000 μM at which NADH decrease was not statistically significant compared to untreated control, and a highly significant increase in the redox ratio at all caffeine doses ( Figure 6 A–C).

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In addition, as shown in Figure 9 D, there was a marginally significant negative correlation between NADH and respiratory severity score (RSS, defined as the fraction of inspired oxygen multiplied by MAP).

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