marginally significantp = 0.02
In the UK Biobank, rs6424532 [ LOC105378800 ] had a statistically significant indirect effect on broad depression through the log of pack-years of cigarette smoking ( p = 4.0 × 10 −4 ) among all participants and a marginally significant indirect effect among females ( p = 0.02) and males ( p = 4.0 × 10 −3 ).