Development and Evaluation of a Water-Free In Situ Depot Gel Formulation for Long-Acting and Stable Delivery of Peptide Drug ACTY116.

However, hydrogen bonds in the water system showed an increasing trend during 100 ns under 373.15 K, which means the secondary structure of ACTY116 changed under high temperature, more amino acids were exposed to water, and more hydrogen bonds were formed between ACTTY116 and water.

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