However, the variability we report in this article is lower than previous reports and may not be significant when more hepatocellular injury is present (such as paracetamol hepatotoxicity).
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Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).
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