CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis-Competent Conformations, Offering Drug Targets.

The pronounced stability of CDK2’s R-spine can be one factor driving its elevated catalytic activity, 13 , 59 a finding that may be significant within the broader cell cycle regulatory mechanisms. 3.3 Stronger and More Robust Interactions between Cyclin-E and CDK2 Than that between Cyclin-D and CDK4 Cyclins are key regulators that promote the activation of CDKs.

also in 13,097 other papers