JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression.

The tumor-subtype and stage-dependent expression of JUN was highly significant when comparing healthy and primary ( p = 2.8e-05), primary and metastatic CRPC ( p = 2.6e-43) and primary and metastatic NEPC ( p = 5.3e-04) (Supplementary Fig. 1g), suggesting JUN as a potential marker of progressive subtypes of PCa.

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