Dose adjustment of paroxetine based on CYP2D6 activity score inferred metabolizer status in Chinese Han patients with depressive or anxiety disorders: a prospective study and cross-ethnic meta-analysis.

In our predefined model, after adjusting for the same demographic covariates, a marginally statistically significant negative effect of AS on paroxetine Css was observed (exponentiated β = 0.90, 95% CI: 0.81–0.999, P = 0.048), which was not significant when further adjusting for daily dose.

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30 In the MDD group, we observed a trend of lower symptom improvement in UMs compared to EMs, which was marginally significant after adjusting for demographic and clinical covariates.

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