Spon1+ inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling.

Using Gene set enrichment analysis (GSEA), we found that SPON1 hi patients showed highly significant enrichment in epithelial-to-mesenchymal transition (EMT) and collagen/ECM-related gene sets ( Figure 2B and Supplemental Table 2 ).

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