Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors.

Cancer Discov · 2024 · PMC11145176 · PMID 38393391

Europe PMC DOI

hedged sentences

0.0480

closest p · 1.0× alpha

0.0503

boldest claim

The sentences

borderline significantP = 0.048actually significant

Although each of these metrics was positively associated with tumor burden, none of these associations were strong, with only CMC demonstrating a borderline significant association (Spearman rho = 0.203, P = 0.048).

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a nonsignificant trendP = 0.0503so close (0.05 < p ≤ 0.1)

There was a nonsignificant trend toward improved PFS in patients with decreased FLS [aHR = 0.51 (0.26–1.00), P = 0.0503; Fig. 4A ].

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