Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus.

Lupus-like disease in mice with the mutation UNC93B1 V117L Given that UNC93B1 V117L is a highly significant risk factor for childhood-onset SLE, but also present in the general population, we sought to confirm pathogenicity in vivo and created mice with the orthologous mutation V117L.

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