Epigenetic and Metabolic Reprogramming of Fibroblasts in Crohn's Disease Strictures Reveals Histone Deacetylases as Therapeutic Targets.

When considered along a composite axis [2PC1–PC2, Figure 2A ], TGFβ treatment induced significant differences [two-way ANOVA, p = 7.5e-10], and the interaction term, which assessed whether the effect of TGFβ was the same in the presence or absence of VPA, was also highly significant [ p = 0.0008] indicating that VPA did indeed alter the response to TGFβ.

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