An integrative epigenome-based strategy for unbiased functional profiling of clinical kinase inhibitors.

Moreover, IRF3 binding to the CREs downregulated by both inhibitors was highly significant (Fig. 6E ), phosphorylation of STAT1 by LPS was reduced (Fig. 6F ) and expression of Ifnb1 as well as IFN-stimulated genes was almost abrogated (Fig. 6G ).

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