Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure.

Lung microbiota clusters predict survival independent of clinical variables and host responses Comparisons of microbial communities between survivors and non-survivors at 60-days post-ICU admission showed highly significant differences in Shannon index, obligate anaerobe and pathogen abundance in lung samples both at baseline and in the middle follow-up interval ( p < 0.05, Figure S11 ).

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Integration of longitudinal and survival analyses with joint modeling showed borderline significant effects for pathogen abundance in the oral compartment and anaerobe abundance in the lung compartment.

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