26 Another issue to be considered is the analysis of different tissues, since mosaicism may not be detected in peripheral blood, but may be significant in tissue samples of different embryonic origin, for example oral mucosa. 26 , 27 , 28 , 29 The presence of Y-chromosome material in individuals with TS can be investigated both cytogenetically and by using various molecular approaches. 30 The latter presents the advantages of not needing cell cultures and requiring only a rather small amount of material.
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