A p -value of less than 0.05 was considered statistically significant, while a p -value of less than 0.01 indicated highly significant differences. 5 Conclusion In conclusion, as shown in Figure 8 , during the combined use of L-arginine and 5-FU, the increase in iNOS expression in HepG2 and SMMC7721 cells caused by 5-FU allows L-arginine to elevate NO level within HCC cells.
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L-arginine combination with 5-fluorouracil inhibit hepatocellular carcinoma cells through suppressing iNOS/NO/AKT-mediated glycolysis.
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