Mitochondrial DNA drives neuroinflammation through the cGAS-IFN signaling pathway in the spinal cord of neuropathic pain mice.

In this study, the detection results of mtDNA in the sciatic nerve of CCI mice showed a significant decrease compared to sham-operated mice, and the extent of the decrease showed an increasing trend over time ( Figure 2b ), reflecting the temporal course of the decrease in pain threshold.

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Notably, an interesting trend emerged: while the expression of STING showed a decrease, its phosphorylation state (p-STING) exhibited an increase.

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