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In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis.

Emerg Microbes Infect · 2024 · PMC11151810 · PMID 38743401

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During the experiment in group A, as the ceftazidime-avibactam MIC increased, there were different results in the carbapenem MICs ( Figure 2 ): the parental strains K1, K2, and K3 showed a gradual decrease in carbapenem MICs during the induction process, whereas K4 showed an increasing trend in carbapenem MICs during induction.

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