Exercise may delay cognitive decline in Chinese older adults: a causal inference for ordered multi-categorical exposures with a Mendelian randomization approach.

In order to better validate the generalizability and stability of our method, we relaxed the selection criterion of p-value to "close to significance" when selecting instrumental variables.

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Specifically, the sub-routine groups significant SNPs into genome segments, that is, clumps, that are independently and significantly associated with the outcome, each indexed by one of the highly significant SNPs within.

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