Barely Significant
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The prognostic value of Dickkopf-3 (Dkk3), TGFB1 and ECM-1 in prostate cancer.

Front Mol Biosci · 2024 · PMC11157039 · PMID 38855324

Europe PMCDOI
3
hedged sentences
0.0820
closest p · 1.6× alpha
0.0820
boldest claim

The sentences

marginally significantp = 0.082so close (0.05 < p ≤ 0.1)
Interestingly, while patients with high DKK3 mRNA expression showed marginally significant lower chance of having recurrence presented as new neoplastic events post initial therapy ( p = 0.082), Patients with higher TGFB1 mRNA expression showed a significant higher chance of recurrence presented as new neoplastic events post initial therapy compared with patients with low TGFB1 mRNA expression ( p < 0.001).

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marginal significancep = 0.082so close (0.05 < p ≤ 0.1)
Our results showed a marginal significance ( p = 0.082) between DKK3 mRNA expression and LN involvement ( Figure 4A ).

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highly significantno p-value reported
The results showed that gene expression level against tumor purity is highly significant for the three biomarkers with negative Spearman’s rho values (−0.5, −0.329 and −0.41), respectively in DKK3, TGFB1 and ECM1 suggesting that these biomarkers are highly expressed in the microenvironment of PCa ( Figure 6 ).

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